Volume 1.01 | Mar 14

Endothelial Cell News 1.01 March 14, 2016
Endothelial Cell News
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TOP STORY
Biodegradable Scaffold with Built-In Vasculature for Organ-on-a-Chip Engineering and Direct Surgical Anastomosis
Scientists report the fabrication of a scaffold that supports the assembly of parenchymal cells on a mechanically tunable matrix surrounding a perfusable, branched, three-dimensional microchannel network coated with endothelial cells. [Nat Mater] Abstract | Press Release
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PUBLICATIONS (Ranked by impact factor of the journal)
Stability and Function of Adult Vasculature Is Sustained by Akt/Jagged1 Signaling Axis in Endothelium
Researchers showed that unlike neovascularization, endothelial Akt signaling in established vasculature is crucial not for endothelial cell survival, but for sustained interactions with pericytes and vascular smooth muscle cells regulating vascular stability and function. [Nat Commun] Full Article

Three-Dimensional Bioprinting of Thick Vascularized Tissues
Investigators report a method for bioprinting 3D cell-laden, vascularized tissues that exceed 1 cm in thickness and can be perfused on chip for long time periods. They integrated parenchyma, stroma, and endothelium into a single thick tissue by coprinting multiple inks composed of human mesenchymal stem cells and human neonatal dermal fibroblasts within a customized extracellular matrix alongside embedded vasculature, which is subsequently lined with human umbilical vein endothelial cells. [Proc Natl Acad Sci USA]
Abstract | Full Article | Press Release | Video

Morphogenesis of 3D Vascular Networks Is Regulated by Tensile Forces
The authors assessed the effect of uniaxial cell-induced and externally applied tensile forces on the morphology of vascular networks formed within fibroblast and endothelial cell-embedded 3D polymeric constructs. [Proc Natl Acad Sci USA] Abstract

Role of Moesin in Advanced Glycation End Products-Induced Angiogenesis of Human Umbilical Vein Endothelial Cells
Researchers investigated the impact of moesin on advanced glycation end product-induced human umbilical vein endothelial cell proliferation, migration, and tubulogenesis. Silencing of moesin decreased cell motility and tube formation but not cell proliferation. [Sci Rep] Full Article

E-Selectin-Targeting Delivery of MicroRNAs by Microparticles Ameliorates Endothelial Inflammation and Atherosclerosis
Scientists tested the hypothesis that delivery of microRNA (miR)-146a and miR-181b with an E-selectin-targeting multistage vector to inflamed endothelium covering atherosclerotic plaques inhibits atherosclerosis. [Sci Rep] Full Article

The Effects of Microvesicles on Endothelial Progenitor Cells Are Compromised in Type 2 Diabetic Patients via Downregulation of miR-126/VEGFR2 Pathway
The effects of circulating microvesicles (MVs) and endothelial progenitor cell (EPC) derived MVs on EPC migration, apoptosis and reactive oxygen species production in healthy controls, well-controlled and uncontrolled diabetic patients were investigated. [Am J Physiol Endocrinol Metab] Abstract

Lymphatic Endothelial Cells Efferent to Inflamed Joints Produce iNOS and Inhibit Lymphatic Vessel Contraction and Drainage in TNF-Induced Arthritis in Mice
Scientists determined the cellular source of inducible nitric oxide synthase (iNOS) induced in lymphatic endothelial cells in response to tumor necrosis factor (TNF), the effects of iNOS on lymphatic smooth muscle cell function and on the development of arthritis in TNF-transgenic mice, and whether iNOS inhibitors improve lymphatic function and reduce joint destruction in inflammatory erosive arthritis. [Arthritis Res Ther] Full Article

Effects of Transplanted Circulating Endothelial Progenitor Cells and Platelet Microparticles in Atherosclerosis Development
Scientists investigated the possible protective role of a cell therapy-based approach using endothelial progenitor cells and the dual behaviour of circulating platelet microparticles on atherosclerosis development in hypertensive-hypercholesterolemic hamster model. [Biol Cell] Abstract

Neuromuscular Electrical Stimulation Acutely Mobilizes Endothelial Progenitor Cells in Critically Ill Patients with Sepsis
Investigators explored the neuromuscular electric stimulation-induced effects on mobilization of endothelial progenitor cells in septic ICU patients. [Ann Intensive Care] Full Article

The Vascular Endothelial Growth Factor Inhibitors Ranibizumab and Aflibercept Markedly Increase Expression of Atherosclerosis-Associated Inflammatory Mediators on Vascular Endothelial Cells
Investigators sought to assess the in vitro effects of Ranibizumab and Aflibercept on the expression of key inflammatory mediators on endothelial cells. [PLoS One] Full Article

A Three-Dimensional Culture System Recapitulates Placental Syncytiotrophoblast Development and Microbial Resistance
Researchers describe a three-dimensional–based culture model using human JEG-3 trophoblast cells that develop syncytiotrophoblast phenotypes when cocultured with human microvascular endothelial cells. JEG-3 cells cultured in this system exhibited enhanced fusogenic activity and morphological and secretory activities strikingly similar to those of primary human syncytiotrophoblasts. [Sci Adv] Abstract | Press Release

Download Mini-Review: Endothelial Progenitor and Endothelial Cells
 
REVIEWS
Concise Review: Endothelial Progenitor Cells in Regenerative Medicine: Applications and Challenges
The authors provide a concise summary of the different endothelial progenitor cell populations being studied for ischemic therapies and their known roles in the healing of ischemic tissues. [Stem Cells Transl Med] Abstract

Visit our reviews page to see a complete list of reviews in the endothelial cell research field.
 
INDUSTRY NEWS
AngioStem™ Inc. Licenses Universal Donor Stem Cell Technology from Queensland University Australia
AngioStem™ Inc. announced signing of an exclusive licensing agreement with Queensland University covering intellectual property on newly discovered placentally derived stem cell populations. The proprietary stem cells are believed to play a role in successful pregnancy by creating new blood vessels that lead to formation and function of the placenta. [AngioStem™ Inc. (Business Wire)] Press Release

EUSA Pharma and AVEO Announce Submission of Marketing Authorization Application for Tivozanib in Advanced Renal Cell Carcinoma
EUSA Pharma and AVEO Oncology announced the submission of a Marketing Authorization Application to the European Medicines Agency for tivozanib for the first-line treatment of advanced renal cell carcinoma. [EUSA Pharma] Press Release

Cancer MoonShot 2020 Community Oncology Milestone: National Immunotherapy Coalition (NIC) Partners with New England Cancer Specialists to Advance Cancer Care in New England
Cancer MoonShot 2020 announced its clinical affiliation with New England Cancer Specialists, aimed to greatly expand patients’ access to advanced cancer care, innovative clinical trials, and survivorship resources in the community. [Cancer MoonShot 2020] Press Release

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POLICY NEWS
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
 
EVENTS
NEW AACR Annual Meeting 2016
April 16-20, 2016
New Orleans, United States

Visit our events page to see a complete list of events in the endothelial cell community.
 
JOB OPPORTUNITIES
NEW Postdoctoral Research Fellow – Angiogenesis and Metabolic Microenvironment Contributing to Carcinogenesis (Beth Israel Deaconess Medical Center – Harvard Medical School)

Postdoctoral Fellow – Ion Channel Signaling and Metabolism (University of Iowa Carver College of Medicine)

Senior Research Fellow – Cancer Biology/Immunology (Plymouth University)

Postdoctoral Position – Cardiovascular Basic and Translational Research (University Clinic Heidelberg)

PhD Student Position – Cardiovascular Basic and Translational Research (University Clinic Heidelberg)

Research Asst Professor/Postdoctoral Fellow Positions – Vascular Biology (University of Illinois)

Postdoctoral Position – Modeling and Analysis of Receptor Interactions (UT Southwestern Medical Center)

Postdoctoral Fellow – Molecular Mechanisms of Angiogenesis and Atherosclerosis (The University of Tennessee Health Science Center)

Postdoctoral Scientist – Isoprenoid Metabolism in Angiogenesis and Cancer (VIB)

PhD Positions – Metabolism and Cancer (VIB)

Postdoctoral Fellow/Research Associate – Translational Genomics and Cancer Immunobiology & Immunotherapy (Children’s Hospital of Philadelphia)


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