Volume 1.06 | Apr 18

Endothelial Cell News 1.06 April 18, 2016
Endothelial Cell News
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More Blood Vessels in Adipose Tissue May Alleviate Type 2 Diabetes
Researchers used recombinant gene transfer technologies to discover a fine-tuning mechanism that can be used to increase the density of blood vessels in adipose tissue. This prevented or even reversed the progression towards type 2 diabetes in animal models. [Press release from University of Helsinki discussing online prepublication in Cell Metabolism] Press Release | Abstract | Graphical Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
Pathological Lymphangiogenesis Is Modulated by Galectin-8-Dependent Crosstalk between Podoplanin and Integrin-Associated VEGFR-3
The authors demonstrated that a carbohydrate-binding protein, galectin-8, promotes pathological lymphangiogenesis. Galectin-8 is markedly upregulated in inflamed human and mouse corneas, and galectin-8 inhibitors reduce inflammatory lymphangiogenesis. [Nat Commun] Abstract | Press Release

Endogenous Transmembrane TNF-Alpha Protects against Premature Senescence in Endothelial Colony Forming Cells
The authors determined the role of transmembrane ™TNF-α in the proliferation of endothelial colony forming cells (ECFCs). They showed that tmTNF-α expression on ECFCs selects for higher proliferative potential and when removed from the cell surface promotes ECFC senescence. [Circ Res] Abstract

MicroRNA-17~92 Inhibits Colorectal Cancer Progression by Targeting Angiogenesis
Researchers found that transgenic mice overexpressing microRNA (miR)-17~92 specifically in epithelial cells of the small and large intestines exhibited decreased tumor size and tumor angiogenesis in azoxymethane and dextran sulfate sodium salt-induced colorectal cancer model as compared to their littermates control. [Cancer Lett] Abstract

EphA1 Activation Promotes the Homing of Endothelial Progenitor Cells to Hepatocellular Carcinoma for Tumor Neovascularization through the SDF-1/CXCR4 Signaling Pathway
Scientists found that the up-regulation of EphA1 expression in hepatocellular carcinoma cells could affect not only the chemotaxis of endothelial progenitor cells (EPCs) to tumor cells and endothelial cells but also the tube formation ability of EPCs in a paracrine fashion. [J Exp Clin Cancer Res] Abstract

Cathepsin L in Tumor Angiogenesis and Its Therapeutic Intervention by the Small Molecule Inhibitor KGP94
The authors examined the contribution of cathepsin L (CTSL) to breast cancer angiogenesis and evaluated the anti-angiogenic efficacy of CTSL inhibitor KGP94. In vitro assessments demonstrated a significant decrease in various angiogenic properties such as endothelial cell sprouting, migration, invasion, tube formation and proliferation in the presence of KGP94. [Clin Exp Metastasis] Abstract

Differentiation of Human CD14+ Monocytes: An Experimental Investigation of the Optimal Culture Medium and Evidence of a Lack of Differentiation along the Endothelial Line
Researchers determined the optimal culturing media for human CD14+ monocytes and evaluated whether these cells are capable of differentiating into vascular endothelial cells. [Exp Mol Med] Full Article

The Proton-Sensing G-Protein Coupled Receptor GPR4 Promotes Angiogenesis in Head and Neck Cancer
Researchers explored the role of GPR4 in acid exposure and tumor angiogenesis in squamous cell carcinoma of the head and neck (SCCHN). They confirmed that overexpressing GPR4 in SCCHN cells could increase the expression and secretion of IL6, IL8 and VEGFA at pH 5.9. [PLoS One] Full Article

Distinctive Role of Vasohibin-1A and Its Splicing Variant Vasohibin-1B in Tumor Angiogenesis
Scientists compared the effects of vasohibin-1 (VASH1)A and VASH1B on tumor angiogenesis. When endothelial cells (ECs) were transfected with VASH1A or VASH1B cDNAs, VASH1B transfectants—but not VASH1A ones—induced autophagic cell death of ECs. [Cancer Gene Ther] Abstract

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Zebrafish (Danio rerio) Embryo as a Platform for the Identification of Novel Angiogenesis Inhibitors of Retinal Vascular Diseases
The authors highlight the use of zebrafish embryo as an innovative model system for the screening of anti-angiogenic molecules to be employed for the treatment of angiogenesis-dependent eye diseases. [Biochim Biophys Acta] Abstract

Visit our reviews page to see a complete list of reviews in the endothelial cell research field.
Ludwig Scientists Share New Findings on Immunotherapy, Drug Resistance and Tumor Evolution
Research conducted by more than 70 Ludwig scientists will be presented in symposiums, plenaries and poster sessions, and Ludwig researchers will participate in several workshops and meet-the-expert sessions over the course of the meeting. [Press release from Ludwig Cancer Research discussing research to be presented at the 2016 American Association for Cancer Research (AACR) Annual Meeting, New Orleans] Press Release

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University of Pennsylvania to Join First-of-Its-Kind Research Collaboration to Fight Cancer with New Immunotherapies
The University of Pennsylvania has joined an unprecedented cancer research effort, the Parker Institute for Cancer Immunotherapy, which unites six of the nation’s top medical schools and cancer centers around a shared aim of accelerating breakthrough immunotherapy research that will turn more cancers into a curable disease. The venture is backed by a $250 million gift from the Parker Foundation, making it the largest single contribution ever made to the field of immunotherapy. [University of Pennsylvania] Press Release

UCLA Joins Collaboration to Advance Cancer Immunotherapy Research
UCLA has joined forces with five of the nation’s other leading cancer centers and The Parker Institute for Cancer Immunotherapy to maximize the potential of cancer immunotherapy research. [UCLA] Press Release
National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)
NEW ISSCR 2016 Annual Meeting
June 22-25, 2016
San Francisco, United States

Visit our events page to see a complete list of events in the endothelial cell community.
NEW Postdoctoral Positions – Translational Research (UConn Health)

NEW Postdoctoral Position – Angiogenesis, Proteases and Extracellular Matrix (GENYO)

NEW PhD Fellowship – Tumor Exosomes (University of Strasbourg)

Faculty Position (University of North Carolina at Chapel Hill)

Postdoctoral Scientist – Leukemia and Lymphoma (Max Delbruck Center for Molecular Medicine in the Helmholtz Association)

Postdoctoral Fellow – Mechanoregulation of Fibrosis and Vascular Injury (St. Michael’s Hospital)

PhD Program – Cell Communication in Health and Disease (Medical University of Vienna)

Postdoctoral Positions – Tissue Repair/Inflammation (Institut Pasteur)

Postdoctoral Research Fellow – Angiogenesis and Metabolic Microenvironment Contributing to Carcinogenesis (Beth Israel Deaconess Medical Center – Harvard Medical School)

Postdoctoral Fellow – Ion Channel Signaling and Metabolism (University of Iowa Carver College of Medicine)

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