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Endothelial Cell News
Endothelial Cell News is an online resource dedicated to the latest research studying the endothelium, blood vessels, and angiogenesis.
Endothelial Cell Expression of a STING Gain-of-Function Mutation Initiates Pulmonary Lymphocytic Infiltration
[Cell Reports] To identify STING-expressing non-hematopoietic cell types required for the development of interstitial lung disease, investigators used a conditional knockin STINGV154M (VM) mutation model and direct expression of the VM allele to hematopoietic cells, fibroblasts, epithelial cells, or endothelial cells.
Vascular Endothelial Dysfunction Induced by 3-Bromofluoranthene via MAPK-Mediated-NFκB Pro-inflammatory Pathway and Intracellular ROS Generation
[Archives Of Toxicology] Disruption of vascular endothelial integrity and up-regulation of vascular endothelial permeability were induced by 3-BrFlu in a concentration-dependent manner through pro-inflammatory responses in vascular endothelial cells, namely, SVEC4-10 cells.
Vascular Mimicry as a Facilitator of Melanoma Brain Metastasis
[Cellular and Molecular Life Sciences] Scientists found that vascular mimicry density was elevated in melanoma brain metastases compared to paired extracranial specimens and was associated with tumor volume and central nervous system edema. Their studies indicated a relevant role of YAP and TAZ, two transcriptional co-factors scarcely studied in melanoma, in tumor cell-vasculogenesis and in brain metastasis.
The Endothelium: Gatekeeper to Lung Ischemia-Reperfusion Injury
[Respiratory Research] The authors highlight the more significant mediators of IRI-induced endothelial dysfunction discovered over the past decade including the extracellular glycocalyx, endothelial ion channels, purinergic receptors, kinases, and integrins.
Mitochondrial CypD Acetylation Promotes Endothelial Dysfunction and Hypertension
[Circulation Research] Researchers studied cyclophilin D (CypD) acetylation in patients with essential hypertension, defined a pathogenic role of CypD acetylation in deacetylation mimetic CypD-K166R mutant mice and endothelial-specific general control of amino acid synthesis 5 like 1–deficient mice using an angiotensin II model of hypertension.
Brain Endothelial GSDMD Activation Mediates Inflammatory BBB Breakdown
[Nature] Scientists found that activation of the pore-forming protein GSDMD by the cytosolic lipopolysaccharide (LPS) sensor caspase-11, but not by TLR4-induced cytokines, mediated BBB breakdown in response to circulating LPS or during LPS-induced sepsis.
Haplo-Insufficiency of Profilin1 in Vascular Endothelial Cells Is Beneficial but Not Sufficient to Confer Protection against Experimentally Induced Atherosclerosis
[Cytoskeleton] The authors investigated the impact of endothelial cell-specific partial loss of profilin1 expression in atherosclerosis development.
SARS-CoV-2 Infection Activates Inflammatory Macrophages in Vascular Immune Organoids
[Scientific Reports] The authors established vascular immune organoids from human pluripotent stem cells and examined the effect of SARS-CoV-2 infection.
Glutamatergic Neuronal Activity Regulates Angiogenesis and Blood-Retinal Barrier Maturation via Norrin/β-Catenin Signaling
[Neuron] Using in vivo genetic studies in mice, scRNA-seq, and functional validation, researchers showed that deep plexus angiogenesis and paracellular blood-retinal barrier maturation were delayed in Vglut1−/− retinas where neurons failed to release glutamate.
Endomucin Selectively Regulates Vascular Endothelial Growth Factor Receptor-2 Endocytosis through Its Interaction with AP2
[Cell Communication and Signaling] The authors investigated the molecular mechanism underlying endomucin’s involvement in the regulation of vascular endothelial growth factor-induced endocytosis.
Anti-Lymphangiogenesis for Boosting Drug Accumulation in Tumors
[Signal Transduction and Targeted Therapy] Investigators verified that anlotinib, a tyrosine kinase inhibitor with anti-lymphangiogenesis activity, and SAR131675, a selective VEGFR-3 inhibitor, effectively decreased the density of tumor lymphatic vessels in mouse cancer models.
Canonical and Non-Canonical Roles of Complement in Atherosclerosis
[Nature Reviews Cardiology] Scientists summarize the classical and the emerging non-classical roles of the complement system in the pathogenesis of atherosclerosis.
Specific research topics covered in Endothelial Cell News include the roles of endothelial cells in the regulation of physiological processes, as well as their implications in tumor progression, cardiovascular disease, endometriosis, wound healing, tissue regeneration and other diseases and disorders. We also provide updates on the latest job postings and upcoming events, helping connect everyone within the endothelial cell research field.
