Endothelial Cell News

Endothelial Cell News is an online resource dedicated to the latest research studying the endothelium, blood vessels, and angiogenesis.

Mast Cell Activation Disrupts Interactions Between Endothelial Cells and Pericytes During Early Life Allergic Asthma

[Journal Of Clinical Investigation] Using quantitative imaging in precision-cut lung slices, scientists reported that exposure of neonatal mice to house dust mite extract disrupted endothelial cell/pericyte interactions in adventitial areas.

Brain-Derived Endothelial Cells Are Neuroprotective in a Chronic Cerebral Hypoperfusion Mouse Model

[Communications Biology] Researchers found brain CD157-positive endothelial cells (ECs) were more proliferative and beneficial in a mouse model of chronic cerebral hypoperfusion than CD157-negative ECs upon inoculation.

Circadian Effects on Vascular Immunopathologies

[Circulation Research] Investigators provide an overview of circadian control of immune-vascular interactions in both the steady state and cardiovascular diseases such as atherosclerosis and infarction.

Medcare Hospital Al Safa Performs Life-Saving Vascular Surgery to Restore Blood Flow to a 72-Year-Old British Expat’s Brain After a Stroke

[UAE News] Ms. Vivienne Alison Davidson, a 72-year-old UK expat, overcame severe carotid artery stenosis, a condition that caused her to have two recurrent strokes, through a complex surgical intervention carried out at Medcare Hospital Al Safa.

Biophysical Interplay between Extracellular Matrix Remodeling and Hypoxia Signaling in Regulating Cancer Metastasis

[Frontiers In Cell And Developmental Biology] Scientists summarize the role of biophysical interactions between cancer cells and their surroundings in determining cancer progression.

Engineering a Heart Conduit: New $2M NIH Grant for Yale Research

[Yale School of Medicine] The National Institutes of Health (NIH) recently awarded Dr. Yibing Qyang, an associate professor of medicine and associate professor of biomedical engineering, and his colleagues in his laboratory a $2+ million R01 grant to support research to create an artificial blood vessel that can grow, pump, and resist infection and clotting.

Endothelial SMAD1/5 Signaling Couples Angiogenesis to Osteogenesis in Juvenile Bone

[Communications Biology] Scientists found that endothelial cell-conditional SMAD1/5 depletion in juvenile mice caused metaphyseal and diaphyseal hypervascularity, resulting in altered trabecular and cortical bone formation.

Hydrogen Sulfide Improves Endothelial Barrier Function by Modulating the Ubiquitination Degradation of KLF4 Through TRAF7 S-sulfhydration in Diabetic Aorta

[Free Radical Biology And Medicine] The authors investigated whether protein S-sulfhydration in the endothelium regulates endothelial integrity and its underlying mechanism.

Deubiquitinase UCHL1 Promotes Angiogenesis and Blood–Spinal Cord Barrier Function Recovery After Spinal Cord Injury by Stabilizing Sox17

[Cellular And Molecular Life Sciences] In vitro Sox17 knockdown attenuated endothelial cell proliferation, migration, and tube formation, while in vivo Sox17 knockdown inhibited endothelial regeneration and barrier recovery, leading to poor functional recovery after spinal cord injury.

Extracellular Vesicles As Central Regulators of Blood Vessel Function in Cancer

[Science Signaling] The authors discuss the translational opportunities in targeting the dysfunctional tumor vasculature using extracellular vesicles (EV) and highlight the open questions in the field of EV biology that can be addressed using mass spectrometry–based proteomics analysis.

Cancer-Associated Fibroblasts Produce Matrix-Bound Vesicles That Influence Endothelial Cell Function

[Science Signaling] Using human mammary cancer-associated fibroblasts (CAFs), investigators showed that CAFs with a myofibroblast phenotype released extracellular vesicles that transferred proteins to endothelial cells that affected their interaction with immune cells.

Vascular ATGL-Dependent Lipolysis and the Activation of cPLA2-PGI2 Pathway Protect against Postprandial Endothelial Dysfunction

[Cellular And Molecular Life Sciences] Researchers characterized the function of lipid droplets and adipose triglyceride lipase-induced lipolysis in the regulation of endothelial function.

Specific research topics covered in Endothelial Cell News include the roles of endothelial cells in the regulation of physiological processes, as well as their implications in tumor progression, cardiovascular disease, endometriosis, wound healing, tissue regeneration and other diseases and disorders. We also provide updates on the latest job postings and upcoming events, helping connect everyone within the endothelial cell research field.

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