Volume 5.21 | Jun 15

2020-06-15 | CSCN 5.21
Endothelial Cell News by STEMCELL Technologies
Vol. 4.30 – 15 June, 2020

Local Mitochondrial ATP Production Regulates Endothelial Fatty Acid Uptake and Transport

Inhibitors of oxidative phosphorylation and the ATP/ADP translocase suppressed FA uptake, pointing principally to ATP production. Decreasing total cellular ATP by blocking glycolysis did not decrease uptake, indicating that specifically mitochondrial ATP was required.
[Cell Metabolism]

AbstractGraphical Abstract

Virtual Conference Exhibition: Pluripotent Stem Cells
PUBLICATIONSRanked by the impact factor of the journal

Neural Metabolic Imbalance Induced by MOF Dysfunction Triggers Pericyte Activation and Breakdown of Vasculature

The authors showed that neural-specific depletion of three members of the non-specific lethal chromatin complex—Mof, Kansl2 or Kansl3—unexpectedly led to severe vascular defects and brain hemorrhaging.
[Nature Cell Biology]


Blockade of VEGF-C Signaling Inhibits Lymphatic Malformations Driven by Oncogenic PIK3CA Mutation

Investigators showed that the somatic PIK3CAH1047R mutation, resulting in constitutive activation of the p110α PI3K, underlaid both macrocystic and microcystic lymphatic malformations (LMs) in human. Using a mouse model of PIK3CAH1047R-driven LMs, they demonstrated that both types of malformations arose due to lymphatic endothelial cell-autonomous defects, with the developmental timing of p110α activation determining the LM subtype.
[Nature Communications]

Full Article

Angiopoietin-2–Integrin α5β1 Signaling Enhances Vascular Fatty Acid Transport and Prevents Ectopic Lipid-Induced Insulin Resistance

Mechanistically, Angpt2 activated integrin α5β1 signaling in the endothelium and triggered fatty acid transport via CD36 and FATP3 into subcutaneous adipose tissue. Genetic or pharmacological inhibition of the endothelial integrin α5β1 recapitulated adipocyte-specific Angpt2 knockout phenotypes.
[Nature Communications]

Full Article

Myeloid ALX/FPR2 Regulates Vascularization Following Tissue Injury

Mechanistically, RNA sequencing revealed that resolvin D1 induced a transcriptional program in macrophages characteristic of a pro-revascularization phenotype. Vascularization of ischemic skeletal muscle, as well as cutaneous wounds, was impaired in mice with myeloid-specific deficiency of Alx/Fpr2, and this was associated with altered expression of pro-revascularization genes in skeletal muscle and macrophages isolated from skeletal muscle.
[Proceedings of the National Academy of Sciences of the United States of America]


Pro-Lymphangiogenic VEGFR-3 Signaling Modulates Memory T Cell Responses in Allergic Airway Inflammation

Researchers explored how pro-lymphangiogenic signaling affects the allergic response to house dust mite. In the acute inflammatory phase, the lungs of mice treated with blocking antibodies against VEGFR-3 displayed less inflammation overall, with dramatically reduced innate and T-cell numbers and reduced inflammatory chemokine levels.
[Mucosal Immunology]


Snail Promotes the Generation of Vascular Endothelium by Breast Cancer Cells

Investigators reported a new and unexpected function of Snail in endothelium generation by breast cancer cells. They showed that high Snail-expressing breast cancer cells isolated from patients showed more endothelium generated from these cells.
[Cell Death & Disease]

Full Article

Cell Type Specific Adhesion to Surfaces Functionalised by Amine Plasma Polymers

The increased resistance observed for the non-endothelial cell types was accompanied by an increased rate of cellular attachment, even though spontaneous migration was comparable to the control, i.e., to the standard cultivation surface. As demonstrated on fibroblasts, the resistance to trypsin was similar in serum-supplemented and serum-free media.
[Scientific Reports]

Full Article

Pneumonia-Induced Endothelial Amyloids Reduce Dendritic Spine Density in Brain Neurons

Researchers used electrophysiological studies in brain slices and structural analysis of post-mortem tissues obtained from animals exposed to endothelium-derived amyloids. The amyloids were administered via three different routes, by intracerebroventricular, intratracheal, and intraperitoneal injections.
[Scientific Reports]

Full Article

miR-503-5p Inhibits Colon Cancer Tumorigenesis, Angiogenesis, and Lymphangiogenesis by Directly Downregulating VEGF-A

Scientists observed considerable downregulation of miR-503-5p expression in colon cancer cells and tissues and significant correlation with the TNM stage, differentiation grade and lymph node metastasis of colon cancer. Overexpression of miR-503-5p promoted the apoptosis and G1 arrest of colon cancer cells, and inhibited migration, proliferation, invasion and colony formation.
[Gene Therapy]


Anti-Angiogenic Effects of Testis-Specific Gene Antigen 10 on Primary Endothelial Cells

Investigators demonstrated that TSGA10 over-expression significantly decreased HUVEC tubulogenesis and interconnected capillary network formation. HUVECs over-expressing TSGA10 exhibited a significant decrease in migration and proliferation rates.


Toxoplasma gondii Infection Impairs Radial Glia Differentiation and Its Potential to Modulate Brain Microvascular Endothelial Cell Function in the Cerebral Cortex

Conditioned medium (CM) from Radial Glia (RG) control cultures increased ZO-1 protein levels and organization on endothelial bEnd.3 cells membranes, which was impaired by CM from infected RG, accompanied by decreased trans-endothelial electrical resistance.
[Microvascular Research]

Full Article

Watch 'collaborating to accelerate COVID-19 research'

Nanotechnology for Angiogenesis: Opportunities and Challenges

The authors summarize nanotechnology-based strategies that have been explored in the broad area of angiogenesis. Lipid-based, carbon-based and polymeric nanoparticles, and a wide range of inorganic and metallic nanoparticles are covered in detail.
[Chemical Society Reviews]

AbstractGraphical Abstract


Hong Kong’s Contentious National Security Law Concerns Some Academics

China’s plan to introduce a new security law in Hong Kong has prompted mixed reactions from scientists there. Some fear that such a law could lead to government interference in research, restrict participation in international collaborations and increase self-censorship, whereas others are confident that research will be unaffected.
[Nature News]


ECU, Vidant Begin Trial of COVID-19 Treatment

Dr. Paul Cook, chief of the Division of Infectious Diseases at East Carolina Univesity’s Brody School of Medicine, began enrolling patients June 1 in a clinical trial investigating a new treatment aimed at preventing and shortening the duration of Acute Respiratory Distress Syndrome (ARDS). ARDS is a characteristic of COVID-19 that occurs when fluid builds up in the lungs and prevents oxygen from entering the bloodstream.
[East Carolina University]

Full Article


2nd Novel Ophthalmology World Congress

2020-06-14 – 2020-06-15
Berlin, Germany

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Postdoctoral Researcher – Single Cell Analysis of Blood Vessels

University of California, San Diego – San Diego, California, United States

Specialist Researcher – Cardiovascular Medicine

UC Davis – Sacramento, California, United States

Postdoctoral Position – Cardiovascular Research

Postdoctoral Research – Bechet’s Disease

University College Dublin – Dublin, Ireland

University of Pittsburgh – Pittsburgh, Pennsylvania, United States

Associate Professor – Neural, Vascular, and Metabolic Biology

The Chinese University of Hong Kong – Hong King, China

Postdoctoral Researcher – Diabetic Endothelial Cell Remodeling

Aarhus University – Aarhus C, Denmark

Postdoctoral Position – Ultrasound-Mediated Phase Transition Contrast Agents for Imaging and Therapy

University of Pittsburgh – Pittsburgh, Pennsylvania, United States

PhD Student Positions – Blood Brain Barrier

Universität Leipzig – Leipzig, Germany

Postdoctoral Positions – Bioinformatics and Vascular Biology

KU Leuven and Sun Yat-Sen University – Various

Postdoctoral Scientist – Gene Editing in Liver Disease

Beam Therapeutics – Cambridge, Massachusetts, United States

> See All Jobs

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