Volume 5.22 | Jun 22

2020-06-22 | ENDOCN 5.22
Endothelial Cell News by STEMCELL Technologies
Vol. 5.22 – 22 June, 2020

Meningeal Lymphatics Clear Erythrocytes That Arise from Subarachnoid Hemorrhage

Scientists showed that a markedly higher number of erythrocytes are accumulated in the lymphatics of cervical lymph nodes and meningeal lymphatics after subarchnoid hemorrhage.
[Nature Communications]

Full Article

Derive and expand human endothelial cells with EC-Cult™-XF Culture Kit.
PUBLICATIONSRanked by the impact factor of the journal

Disseminated Melanoma Cells Transdifferentiate into Endothelial Cells in Intravascular Niches at Metastatic Sites

Researchers combined lineage tracing in a spontaneous metastatic mouse model of melanoma, advanced imaging, and single-cell RNA sequencing approaches to search for pathophysiologically relevant melanoma cellular states.
[Cell Reports]

Full ArticleGraphical Abstract

The Pericyte Connectome: Spatial Precision of Neurovascular Coupling Is Driven by Selective Connectivity Maps of Pericytes and Endothelial Cells and Is Disrupted in Diabetes

Pericytes connected predominantly to other neighboring pericytes and endothelial cells, and less to arteriolar smooth muscle cells, and not to surrounding neurons or glia.
[Cell Discovery]


Drop-on-Demand Cell Bioprinting via Laser Induced Side Transfer (LIST)

Researchers showed that LIST-printed HUVECS present negligible loss of viability and maintain their abilities to migrate, proliferate and form intercellular junctions.
[Scientific Reports]

Full Article

Multicellular 3D Neurovascular Unit Model for Assessing Hypoxia and Neuroinflammation Induced Blood-Brain Barrier Dysfunction

Scientists employed a multicellular 3D neurovascular unit organoid containing human brain microvascular endothelial cells, pericytes, astrocytes, microglia, oligodendrocytes and neurons to model the effects of hypoxia and neuroinflammation on blood-brain barrier function.
[Scientific Reports]

Full Article

Biallelic MFSD2A Variants Associated with Congenital Microcephaly, Developmental Delay, and Recognizable Neuroimaging Features

Major Facilitator Superfamily Domain containing 2a (MFSD2A) is an essential endothelial lipid transporter at the blood-brain barrier. Researchers carried out a detailed analysis of the clinical and neuroradiological features of a series of 27 MCPH15 cases, including eight new individuals from seven unrelated families.
[European Journal of Human Genetics]

Full Article

ADP Receptor P2y12 Prevents Excessive Primitive Hematopoiesis in Zebrafish by Inhibiting Gata1

By using mass spectrometry combined with RNA sequencing, scientists showed that absence of P2y12 induced excessive erythropoiesis, evidenced by significantly increased expression of mature erythrocytes marker α-globin, β-globin.
[Acta Pharmacologica Sinica]


Fabrication of Stiffness Gradients of GelMA Hydrogels Using a 3D Printed Micromixer

A co-culture consisting of human adipose tissue-derived mesenchymal stem cells and HUVECs was encapsulated in the gradient construct.
[Macromolecular Bioscience]

Full Article

Enhanced Vascularization and Biocompatibility of Rat Pancreatic Decellularized Scaffolds Loaded with Platelet-Rich Plasma

Investigators evaluated rat pancreatic decellularized scaffold loaded with platelet-rich plasma for vascularization, host inflammatory response and macrophage polarization in an animal model.
[Journal of Biomaterials Applications]



The Vascular Endothelium: The Cornerstone of Organ Dysfunction in Severe SARS-CoV-2 Infection

Venous thrombotic events, particularly pulmonary embolism, with elevated D-dimer and coagulation activation are highly prevalent in COVID-19 patients. The pro-inflammatory cytokine storm, with elevated levels of interleukin-6 (IL-6), IL-2 receptor, and tumor necrosis factor-α, could also participate in endothelial dysfunction and leukocyte recruitment in the microvasculature.
[Critical Care]

Full Article

The Importance of Mechanical Forces for In Vitro Endothelial Cell Biology

The authors review what is known about the mechanical forces that guide endothelial cell behavior and then discuss the advancements in endothelial cell culture models designed to better mimic the in vivo vascular microenvironment.
[Frontiers in Physiology]

Full Article


Chi-Med Announces Fruquintinib Granted US FDA Fast Track Designation for Metastatic Colorectal Cancer

Hutchison China MediTech Limited announced that the FDA has granted Fast Track Designation for the development of fruquintinib, for the treatment of patients with metastatic colorectal cancer who have been previously treated with fluoropyrimidine-, oxaliplatin-, and irinotecan-based chemotherapy, an anti-VEGF biological therapy, and, if RAS wild-type, an anti-epidermal growth factor receptor therapy.
[Hutchison China MediTech Limited ]

Press Release

NMPA Accepts Bio-Thera Solutions’ Biologics License Application (BLA) for BAT1706, A Proposed Biosimilar to Avastin®

Bio-Thera Solutions announced that the China National Medical Products Administration (NMPA) has accepted the Biologics License Application for BAT1706, a proposed biosimilar to Avastin®.
[Bio-Thera Solutions (Business Wire, Inc.)]

Press Release


Micro-CT: Fancy Gadget or Indispensable Technology towards Accurate Quantification of Lung Disease and Therapy?


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Research Fellow – Endothelial and Cardiomyocyte Remodeling in Insulin Resistance

Queen’s University Belfast – Belfast, United Kingdom

Postdoctoral Fellow – Non-Coding RNAs in Vascular Disease

The Brigham and Women’s Hospital – Boston, Massachusetts, United States

Postdoctoral Researcher – Single Cell Analysis of Blood Vessels

University of California, San Diego – San Diego, California, United States

Specialist Researcher – Cardiovascular Medicine

UC Davis – Sacramento, California, United States

Postdoctoral Position – Cardiovascular Molecular Mechanics

Spanish National Center for Cardiovascular Research – Madrid, Spain

Associate Professor – Neural, Vascular, and Metabolic Biology

The Chinese University of Hong Kong – Hong King, China

Postdoctoral Position – Ultrasound-Mediated Phase Transition Contrast Agents for Imaging and Therapy

University of Pittsburgh – Pittsburgh, Pennsylvania, United States

PhD Student Positions – Blood Brain Barrier

Universität Leipzig – Leipzig, Germany

Postdoctoral Positions – Bioinformatics and Vascular Biology

KU Leuven and Sun Yat-Sen University – Various

Postdoctoral Scientist – Gene Editing in Liver Disease

Beam Therapeutics – Cambridge, Massachusetts, United States

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