Volume 5.23 | Jun 29

2020-29-06 | ENDO 5.23
Endothelial Cell News by STEMCELL Technologies
Vol. 5.23 – 29 June, 2020
TOP STORY

Generation of Model Tissues with Dendritic Vascular Networks via Sacrificial Laser-Sintered Carbohydrate Templates

Investigators showed that cell-laden hydrogels could be patterned with algorithmically generated dendritic vessel networks and other complex hierarchical networks by using sacrificial templates made from laser-sintered carbohydrate powders.
[Nature Biomedical Engineering]

Abstract
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PUBLICATIONSRanked by the impact factor of the journal

An Autophagic Deficit in the Uterine Vessel Microenvironment Provokes Hyperpermeability through Deregulated VEGFA, NOS1, and CTNNB1

Deletion of Atg7 was confirmed by functional deficit of autophagy in uterine stromal, myometrial, and vascular smooth muscle cells, but not in endothelial cells.
[Autophagy]

Abstract

Platelet-Specific PDGFB Ablation Impairs Tumor Vessel Integrity and Promotes Metastasis

Scientists showed that tumor vascular function as well as pericyte coverage was significantly impaired in mice with conditional knockout of platelet-derived growth factor (PDGFB) in platelets.
[Cancer Research]

Abstract

A Versatile Microfluidic Device for Multiple Ex Vivo/In Vitro Tissue Assays Unrestrained from Tissue Topography

Using irregular tissues such as an aorta, scientists conducted multiple in vitro and ex vivo assays on tissue sections, including short-term culturing, a drug toxicity assay, a fluorescence immunohistochemistry staining assay, and an immune cell assay, in which they observed the interaction of neutrophils with lipopolysaccharide-stimulated endothelium.
[Microsystems & Nanoengineering]

Full Article

Hyaloid Vasculature and mmp2 Activity Play a Role during Optic Fissure Fusion in Zebrafish

Pharmacological inhibition of VEGF signaling phenocopied the pax2a−/− vasculature, F-actin and basement membrane degradation phenotypes.
[Scientific Reports]

Full Article

Decreased miR-200b-3p in Cancer Cells Leads to Angiogenesis in HCC by Enhancing Endothelial ERG Expression

Researchers investigated whether hepatocyte-derived miR-200b-3p governed angiogenesis in hepatocellular carcinoma (HCC) by targeting endothelial erythroblast transformation-specific-related gene (ERG).
[Scientific Reports]

Full Article

Vascular Permeability Disruption Explored in the Proteomes of Mouse Lungs and Human Microvascular Cells following Acute Bromine Exposure

Investigators surveyed the lung proteomes of C57BL/6 male mice and human lung derived microvascular endothelial cells at 24 hours following exposure to bromine in concentrations likely to be encountered in the vicinity of industrial accidents.
[American Journal of Physiology-Lung Cellular and Molecular Physiology]

Abstract

Exoenzyme Y Induces Extracellular Active Caspase-7 Accumulation Independent from Apoptosis: Modulation of Transmissible Cytotoxicity

To study the function of extracellular caspase-7, caspase-7- and caspase-3-deficient pulmonary microvascular endothelial cells were generated using CRISPR/Cas9 technology.
[American Journal of Physiology-Lung Cellular and Molecular Physiology]

Abstract

A Somatic Activating KRAS Variant Identified in an Affected Lesion of a Patient with Gorham–Stout Disease

To explore the pathogenesis of Gorham–Stout disease (GSD), scientists performed the amplicon-based deep sequencing on 50 cancer-related genes to assay affected tissues from the six patients with GSD.
[Journal of Human Genetics]

Abstract

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REVIEWS

New Tools to Prevent Cancer Growth and Spread: A ‘Clever’ Approach

Clever-1 (also known as Stabilin-1 and FEEL-1) is a scavenger receptor expressed on lymphatic endothelial cells, sinusoidal endothelial cells and immunosuppressive monocytes and macrophages.
[British Journal of Cancer]

Full Article

LIPG: An Inflammation and Cancer Modulator

Since endothelial lipase predominantly functions as a phospholipase as well as presents low levels of triglyceride lipase activity, it plays an essential role in lipoprotein metabolism, and involves metabolic syndromes such as inflammatory response and atherosclerosis.
[Cancer Gene Therapy]

Abstract

INDUSTRY AND POLICY NEWS

NIH’s New Sexual-Harassment Rules Are Still Too Weak, Say Critics

On 24 June, the US National Institutes of Health (NIH) described the actions it will take when alerted to reports of unsafe behavior, including restricting scientists from peer-review panels, holding back pending grants and refusing university requests to transfer funding to other institutions in cases where a harasser changes jobs.
[Nature News]

Press Release

Graduate Programs Drop GRE after Online Version Raises Concerns about Fairness

Scores of academics have raised concerns about the equity of the online version of the test, arguing it disadvantages prospective students from rural and low-income backgrounds. “If I were … a student trying to take this exam, satisfying criteria would be extremely difficult for me,” says Emily Levesque, an assistant professor of astronomy at the University of Washington, Seattle.
[ScienceInsider]

Press Release

FEATURED EVENT

The Neurovascular Interface

September 14 – September 16
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JOB OPPORTUNITIES

Postdoctoral Fellow – Endothelial Cells in the Blood-Brain Barrier

The University of Texas Health Science Center at Houston – Houston, Texas, United States

Research Fellow – Endothelial and Cardiomyocyte Remodeling in Insulin Resistance

Queen’s University Belfast – Belfast, United Kingdom

Postdoctoral Fellow – Non-Coding RNAs in Vascular Disease

The Brigham and Women’s Hospital – Boston, Massachusetts, United States

Postdoctoral Researcher – Single Cell Analysis of Blood Vessels

University of California, San Diego – San Diego, California, United States

Specialist Researcher – Cardiovascular Medicine

UC Davis – Sacramento, California, United States

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