Volume 5.24 | Jul 6

2020-07-06 | ENDOCN 5.24
Endothelial Cell News by STEMCELL Technologies
Vol. 5.24 – 06 July, 2020
TOP STORY

Altered Properties of Endothelial Cells and Mesenchymal Stem Cells Underlying the Development of Scleroderma-Like Vasculopathy in Klf5+/-; Fli1+/- Mice

Neovascularization and angiogenesis were assessed by in vivo Matrigel plug assay and in vitro tube formation assay, respectively.
[Arthritis & Rheumatology]

Abstract

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PUBLICATIONSRanked by the impact factor of the journal

Self-Assembled Dodecyl Group-Modified Gelatin Microparticle-Based Hydrogels with Angiogenic Properties

Investigators designed a novel angiogenic microparticle comprising Alaska pollock-derived gelatin modified with a dodecyl group to stimulate endogenous VEGF secretion.
[NPG Asia Materials]

Full Article

EGFR/Ras-Induced CCL20 Production Modulates the Tumor Microenvironment

The effects of CCL20 on endothelial cell migration and tumor-associated vascularisation were comprehensively analysed with chemotaxis assays in vitro and in CCR6-deficient mice in vivo.
[British Journal of Cancer]

Abstract

β-Catenin Promotes Endothelial Survival by Regulating eNOS Activity and Flow-Dependent Anti-Apoptotic Gene Expression

Researchers found that β-catenin depleted HUVEC stimulated with pharmacological activators of endothelial NO synthase (eNOS) showed a reduction in eNOS phosphorylation as well as reduced intracellular cyclic guanosine monophosphate levels compared to control cells in static cultures.
[Cell Death & Disease]

Full Article

Splice Variants of lncRNA RNA ANRIL Exert Opposing Effects on Endothelial Cell Activities Associated with Coronary Artery Disease

Overexpression of ANRIL transcript NR_003529 increased monocyte adhesion to endothelial cells (ECs) and transendothelial monocyte migration (TEM), whereas knockdown of NR_003529 expression reduced monocyte adhesion to ECs and TEM.
[RNA Biology]

Abstract

Role of Endothelial Microvesicles Released by p-Cresol on Endothelial Dysfunction

An in vitro model of endothelial damage mediated by p-cresol (PcEMV) was proposed to evaluate the functional effect of PcEMV on the endothelial repair process carried out by endothelial cells and microRNA that could be involved in this process.
[Scientific Reports]

Full Article

Increased Levels of VEGF-C and Macrophage Infiltration in Lipedema Patients without Changes in Lymphatic Vascular Morphology

The histological and molecular characterization was conducted on anatomically-matched skin and fat biopsies as well as serum samples from eleven lipedema and ten BMI-matched healthy patients.
[Scientific Reports]

Full Article

A Convenient Approach by Using Poly-(HEMA-Co-NIPAM)/Cu2+ Solution Sol–Gel Transition for Wound Protection and Healing

Poly‐(HEMA‐co‐NIPAM) solution incorporated with copper ions not only exhibited excellent antibacterial properties, but also expedited wound closure and facilitated tissue angiogenesis.
[Journal of Biomedical Materials Research Part B-Applied Biomaterials]

Abstract

Zeb1 Promotes Corneal Neovascularization by Regulation of Vascular Endothelial Cell Proliferation

Investigators showed that Zeb1 is an important factor promoting vascular endothelial cell (EC) proliferation and corneal neovascularization (NV); and a couple of small molecule inhibitors can evict Ctbp from the Zeb1–Ctbp complex, thereby reducing EC Zeb1 expression, proliferation, and corneal NV.
[Communications Biology]

Full Article

Virtual Conference Exhibition: Pluripotent Stem Cells
REVIEWS

Basic and Therapeutic Aspects of Angiogenesis Updated

The authors focus on some recent advances in understanding endothelial cell behavior in health and disease and identify novel molecular players and concepts that could eventually be considered for therapeutic targeting.
[Circulation Research]

Full Article

Uncovering Mutation-Specific Morphogenic Phenotypes and Paracrine-Mediated Vessel Dysfunction in a Biomimetic Vascularized Mammary Duct Platform

Scientists introduced a 3D microfluidic platform that juxtaposes a human mammary duct in proximity to a perfused endothelial vessel.
[Nature Communications]

Full Article

Extracellular Matrix Dynamics in Vascular Remodeling

The authors summarize how extracellular matrix (ECM) dynamics control vascular remodeling, and further indicate potential diagnostic biomarkers and therapeutic targets in the ECM for corresponding vascular diseases.
[American Journal of Physiology-Cell Physiology]

Abstract

INDUSTRY AND POLICY NEWS

Completion of Patient Dosing in Cohort 4 of the OPTIC Phase I Trial of ADVM-022 Single Injection Gene Therapy for Wet AMD

Adverum Biotechnologies, Inc. announced the completion of patient dosing in Cohort 4 of OPTIC, a Phase I clinical trial, assessing a single intravitreal injection of ADVM-022 in patients with wet age-related macular degeneration (AMD).
[Adverum Biotechnologies]

Press Release

Initiative Recruits Scientist-Volunteers to Aid COVID-19 Research

In mid-March, as businesses and universities across Europe were shutting down in a bid to slow the COVID-19 pandemic, three longtime friends were talking about how they wished they could do something to combat the disease.
[The Scientist]

Editorial

Amidst Uncertainty, Flexibility Is Key in Higher Ed, Faculty Say

Life sciences professors and other staff make contingency plans for more coronavirus-related disruptions in the coming school year.
[The Scientist]

Editorial

FEATURED EVENT

The New York Stem Cell Foundation (NYSCF) Conference

October 20 – October 21
Virtual

> See All Events

JOB OPPORTUNITIES

Professor – Endothelial Cell Biology

Universitätsklinikum Bonn – Bonn, Germany

Postdoctoral Fellow – Endothelial Cells in the Blood-Brain Barrier

The University of Texas Health Science Center at Houston – Houston, Texas, United States

Research Fellow – Endothelial and Cardiomyocyte Remodeling in Insulin Resistance

Queen’s University Belfast – Belfast, United Kingdom

Postdoctoral Fellow – Non-Coding RNAs in Vascular Disease

The Brigham and Women’s Hospital – Boston, Massachusetts, United States

Postdoctoral Researcher – Single Cell Analysis of Blood Vessels

University of California, San Diego – San Diego, California, United States

> See All Jobs

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