Volume 1.00 | Mar 7

Endothelial Cell News 1.00 March 7, 2016
Endothelial Cell News
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MT1-MMP Sheds LYVE-1 on Lymphatic Endothelial Cells and Suppresses VEGF-C Production to Inhibit Lymphangiogenesis
The authors report that membrane type 1-matrix metalloproteinase (MT1-MMP) is an endogenous suppressor of lymphatic vessel growth. MT1-MMP-deficient mice exhibit spontaneous corneal lymphangiogenesis without concomitant changes in angiogenesis. [Nat Commun] Full Article
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PUBLICATIONS (Ranked by impact factor of the journal)
Chronic Stress in Mice Remodels Lymph Vasculature to Promote Tumor Cell Dissemination
Scientists showed that chronic stress restructures lymphatic networks within and around tumors to provide pathways for tumor cell escape. They showed that VEGFC derived from tumor cells is required for stress to induce lymphatic remodeling and that this depends on COX2 inflammatory signaling from macrophages. [Nat Commun] Full Article | Press Release

The Initiator Methionine tRNA Drives Secretion of Type II Collagen from Stromal Fibroblasts to Promote Tumor Growth and Angiogenesis
Researchers generated a mouse expressing additional copies of the tRNAiMet gene (2+tRNAiMet mouse). Growth and vascularization of subcutaneous tumor allografts was enhanced in 2+tRNAiMet mice compared with wild-type littermate controls. Extracellular matrix deposited by fibroblasts from 2+tRNAiMet mice supported enhanced endothelial cell and fibroblast migration. [Curr Biol] Abstract | Press Release

Endothelial Cell Survival during Angiogenesis Requires the Pro-Survival Protein MCL1
Scientists investigated the in vivo role of myeloid cell leukemia 1 (MCL1), a pro-survival member of the BCL2 family, in endothelial cell (EC) survival during angiogenesis. EC-specific deletion of Mcl1 resulted in a dose-dependent increase in EC apoptosis in the angiogenic vasculature and a corresponding decline in vessel density. [Cell Death Differ] Abstract

Endothelial Cells Decode VEGF-Mediated Ca2+ Signaling Patterns to Produce Distinct Functional Responses
Researchers found that VEGF triggers proliferation or migration in endothelial cells by stimulating different calcium signaling patterns. [Sci Signal] Abstract

Three-Dimensional Characterization of Mechanical Interactions between Endothelial Cells and Extracellular Matrix during Angiogenic Sprouting
Researchers studied the three-dimensional cell-extracellular matrix interactions of endothelial cells that form multicellular structures called sprouts. They analyzed data collected in-situ from angiogenic sprouting experiments and identified the differentiated interaction behavior exhibited by the tip and stalk cells. [Sci Rep] Full Article

Tumor-Induced Remote ECM Network Orientation Steers Angiogenesis
Investigators use automated sequential microprinting of tumor and endothelial cells in extracellular matrix (ECM) scaffolds to study its mechanical aspects. Quantitative reflection microscopy shows that tumor spheroids induce radial orientation of the surrounding collagen fiber network up to a distance of five times their radius. [Sci Rep] Full Article

Advanced Age Decreases Local Calcium Signaling in Endothelium of Mouse Mesenteric Arteries In Vivo
Scientists tested the hypothesis that local endothelial cell Ca2+ signaling is impaired with advanced age along with a reduction in internal elastic lamina holes. [Am J Physiol Heart Circ Physiol] Abstract

Inhibition of Development of Laser-Induced Choroidal Neovascularization with Suppression of Infiltration of Macrophages in Smad3-Null Mice
The authors evaluated the effects of the loss of Smad3 on the development of experimental argon laser-induced choroidal neovascularization in mice. An in vitro angiogenesis model was also used to examine the role of transforming growth factor-β1/Smad3 signaling in vessel-like tube formation by human umbilical vein endothelial cells. [Lab Invest] Abstract

Abnormal Correlation of Circulating Endothelial Progenitor Cells and Endothelin-1 Concentration May Contribute to the Development of Arterial Hypertension in Childhood Acute Lymphoblastic Leukemia Survivors
Investigators determined the relationship between the rate of circulating endothelial progenitor cells and plasma levels of endothelin-1 with respect to hypertension in childhood acute lymphoblastic leukemia survivors. [Hypertens Res] Abstract

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Endothelial Progenitor Cells (EPCs) in Aging and Age-Related Diseases: How Currently Available Treatment Modalities Affect EPC Biology, Atherosclerosis, and Cardiovascular Outcomes
In this review, the effect of currently available treatment options for cardiovascular and metabolic disorders on EPC biology is discussed. The various EPC-based therapies that are discussed include lipid-lowering agents, antihypertensive agents, antidiabetic drugs, phosphodiesteraze inhibitors, hormones, as well as EPC capturing stents. [Mech Ageing Dev] Abstract

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Batu Biologics Recruits Diagnostics Expert to Oversee Precision-Medicine Company Arm
Batu Biologics, an immuno-oncology company dedicated to the development of its tumor-angiogenesis targeting immune therapy, ValloVax™, announced the appointment of Vijay Mahant, PhD, to its Scientific Advisory Board. [Batu Biologics (Business Wire)] Press Release

Chi-Med Initiates Sulfatinib Phase II Clinical Trial in Thyroid Cancer
Hutchison China MediTech Limited announced that Hutchison MediPharma Limited has initiated an open-label Phase II clinical trial to evaluate the efficacy and safety of sulfatinib in patients with locally advanced or metastatic radioactive iodine-refractory differentiated thyroid cancer or medullary thyroid cancer in China [Hutchison China MediTech Limite] Press Release

Exelixis and Ipsen Enter into Exclusive Licensing Agreement to Commercialize and Develop Novel Cancer Therapy Cabozantinib in Regions Outside the United States, Canada and Japan
Exelixis, Inc. and Ipsen jointly announced an exclusive licensing agreement for the commercialization and further development of cabozantinib, Exelixis’ lead oncology drug. Under the agreement, Ipsen will have exclusive commercialization rights for current and potential future cabozantinib indications outside of the United States, Canada and Japan. [Exelixis, Inc.] Press Release

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NEW Tumor Microenvironment and Signaling
April 3-6, 2016
Heidelberg, Germany

NEW 12th International Conference of the Asian Clinical Oncology Society
April 8-10, 2016
New Delhi, India

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Postdoctoral Fellow – Ion Channel Signaling and Metabolism (University of Iowa Carver College of Medicine)

Senior Research Fellow – Cancer Biology/Immunology (Plymouth University)

Postdoctoral Position – Cardiovascular Basic and Translational Research (University Clinic Heidelberg)

PhD Student Position – Cardiovascular Basic and Translational Research (University Clinic Heidelberg)

Postdoctoral Research Scientist – Wound Healing and Inflammation (Inserm)

Research Asst Professor/Postdoctoral Fellow Positions – Vascular Biology (University of Illinois)

Postdoctoral Position – Modeling and Analysis of Receptor Interactions (UT Southwestern Medical Center)

Postdoctoral Fellow – Molecular Mechanisms of Angiogenesis and Atherosclerosis (The University of Tennessee Health Science Center)

Postdoctoral Scientist – Isoprenoid Metabolism in Angiogenesis and Cancer (VIB)

PhD Positions – Metabolism and Cancer (VIB)

Postdoctoral Fellow/Research Associate – Translational Genomics and Cancer Immunobiology & Immunotherapy (Children’s Hospital of Philadelphia)

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