Volume 1.02 | Mar 21

Endothelial Cell News 1.02 March 21, 2016
Endothelial Cell News
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Akt Regulates Progesterone Receptor B-Dependent Transcription and Angiogenesis in Endometrial Cancer Cells
To determine the ramifications of MK-2206 (MK)+progestin (R5020) treatment on angiogenesis, in vitro assays were performed and combinatorial MK+R5020 treatment significantly decreased endothelial cell invasion and tube formation more than MK or R5020 treatment alone. [Oncogene] Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
Identification of IL-23p19 as an Endothelial Proinflammatory Peptide that Promotes gp130-STAT3 Signaling
The authors found that intercellular interleukin-23 (IL-23)p19 increased the cell surface abundances of intercellular adhesion molecule–1 and vascular cell adhesion molecule–1 on endothelial cells, which enhanced the attachment of leukocytes and increased their transendothelial migration. [Sci Signal] Abstract | Editorial

Loss of Reelin Protects against Atherosclerosis by Reducing Leukocyte–Endothelial Cell Adhesion and Lesion Macrophage Accumulation
In cultured human endothelial cells, Reelin enhanced monocyte adhesion and increased intercellular adhesion molecule–1, vascular cell adhesion molecule–1, and E-selectin expression by suppressing endothelial nitric oxide synthase activity and increasing nuclear factor κB activity in an apolipoprotein E receptor 2-dependent manner. [Sci Signal] Abstract | Editorial

N-Acetylgalactosamine Glycans Function in Cancer Cell Adhesion to Endothelial Cells: A Role for Truncated O-Glycans in Metastatic Mechanisms
The authors provide evidence of a functional role for aberrant N-acetylgalactosamine-glycans in cancer cell capture from blood flow and/or adhesion to endothelium. Adhesion of breast cancer cells to human umbilical vein endothelial cell monolayers was modeled under sweeping flow. [Cancer Lett] Abstract

Roles of Endothelial A-Type Lamins in Migration of T Cells on and under Endothelial Layers
Researchers altered nuclear stiffness of endothelial cells (ECs) by reducing the expression of A-type lamins using siRNA, and investigated the migration of T cells on and under EC layers. [Sci Rep] Full Article

Estrogen Enhances Linkage in the Vascular Endothelial Calmodulin Network via a Feedforward Mechanism at the G Protein-Coupled Estrogen Receptor 1
Investigators showed that 17-β-estradiol upregulates total calmodulin (CaM) level in endothelial cells. Concurrent measurement of Ca2+ and Ca2+-CaM indicated that 17-β-estradiol also increases free Ca2+-CaM. [J Biol Chem] Abstract | Full Article

A20 Deficiency Leads to Angiogenesis of Pulmonary Artery Endothelial Cells through Stronger NF-κB Activation under Hypoxia
Scientists found a transient elevation of A20 expression in the lung tissues from hypoxic rats compared with normoxic controls. This rapid enhancement was mainly detected in the endothelium, and similar results were reproduced in vitro. [J Cell Mol Med] Full Article

Comparison of Growth & Function of Endothelial Progenitor Cells Cultured on Deproteinized Bovine Bone Modified with Covalently Bound Fibronectin and Bound Vascular Endothelial Growth Factor
The authors assessed and compared the growth and function of endothelial progenitor cells cultured on covalently bonded vascular endothelial growth factor and covalently bonded fibronectin coating on deproteinized bovine bone (DBB), compared to non-modified DBB blocks. [Clin Oral Implants Res] Abstract

Hypoxic Conditioned Medium from Mesenchymal Stem Cells Promotes Lymphangiogenesis by Regulation of Mitochondrial-Related Proteins
To investigate the effects of mesenchymal stem cell-secreted factors in starved human lymphatic endothelial cells (hLEC), hLECs were treated with endothelial basal medium-2, normoxic conditioned media, or hypoxic conditioned media in vitro and in vivo. [Stem Cell Res Ther] Full Article

TNF-Alpha Promotes Lymphangiogenesis and Lymphatic Metastasis of Gallbladder Cancer through the ERK1/2/AP-1/VEGF-D Pathway
The role of the tumor necrosis factor-alpha (TNF-α)-vascular endothelial growth factor D (VEGF-D) axis in the tube formation of human dermal lymphatic endothelial cells was determined using a three-dimensional coculture system. The role of the TNF-α – VEGF-D axis in lymphangiogenesis and lymph node metastasis was studied via animal experiment. [BMC Cancer] Full Article

PKM2 Released by Neutrophils at Wound Site Facilitates Early Wound Healing by Promoting Angiogenesis
Researchers report that infiltrated/activated neutrophils at wound site release pyruvate kinase M2 (PKM2) by its secretive mechanisms during early stages of wound repair. The released extracellular PKM2 facilitates early wound healing by promoting angiogenesis at wound site. [Wound Repair Regen] Abstract | Press Release

Inhibition of Wnt Inhibitory Factor 1 under Hypoxic Condition in Human Umbilical Vein Endothelial Cells Promoted Angiogenesis In Vitro
Researchers investigated the function of Wnt inhibitory factor 1 on placental angiogenesis in human umbilical vein endothelial cells under hypoxic conditions. [Reprod Sci] Abstract

Long Noncoding RNA Highly Upregulated in Liver Cancer Regulates the Tumor Necrosis Factor-α-Induced Apoptosis in Human Vascular Endothelial Cells
Researchers demonstrated the role of long noncoding RNA highly upregulated in liver cancer (HULC) in tumor necrosis factor-α (TNF-α)-induced apoptosis. HULC expression was decreased with TNF-α treatment. [DNA Cell Biol] Abstract

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Mitochondrial Signaling in the Vascular Endothelium: Beyond Reactive Oxygen Species
Recent studies have identified a host of mitochondria-linked factors that influence the cellular and extracellular environments, including mitochondria-derived peptides, mitochondria-localized proteins, and the mitochondrial genome itself. Many of these factors help orchestrate reactive oxygen species (ROS) homeostasis and ROS-related signaling. The paradigm defining the role of mitochondria in the vasculature needs to be updated yet again to include these key signaling factors, which serves as the focus of the current review. [Basic Res Cardiol] Full Article

When the Endothelium Scores an Own Goal: Endothelial Cells Actively Augment Metastatic Extravasation through Endothelial-Mesenchymal Transition
Evidence suggests that endothelial cells are not passive actors during transendothelial migration (TEM) of cancer cells, there are profound changes in endothelial junctional protein expression, signaling, permeability and contractility. The authors describe these alterations in endothelial characteristics during TEM of metastatic tumor cells and discussed them in the context of endothelial-mesenchymal transition. [Am J Physiol Heart Circ Physiol] Abstract

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Chi-Med Initiates Sulfatinib Phase III Registration Study in Pancreatic Neuroendocrine Tumor Patients
Hutchison China MediTech Limited announced that Hutchison MediPharma Limited, its drug R&D subsidiary, has initiated SANET-p, a Phase III registration trial of sulfatinib in China in patients with pancreatic neuroendocrine tumors. [Hutchison China MediTech Limited] Press Release

SRI International Receives $19.8 Million National Cancer Institute Contract for PREVENT Cancer Program
SRI International has been awarded a contract of up to $19.8 million from the National Cancer Institute PREVENT Cancer Preclinical Drug Development Program to support the development of potential cancer preventive agents or vaccines. [SRI International] Press Release

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NEW The Controlling Cancer Summit 2016
May 17-19, 2016
London, United Kingdom

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NEW Postdoctoral Positions – Tissue Repair/Inflammation (Institut Pasteur)

Postdoctoral Research Fellow – Angiogenesis and Metabolic Microenvironment Contributing to Carcinogenesis (Beth Israel Deaconess Medical Center – Harvard Medical School)

Postdoctoral Fellow – Ion Channel Signaling and Metabolism (University of Iowa Carver College of Medicine)

Senior Research Fellow – Cancer Biology/Immunology (Plymouth University)

Research Asst Professor/Postdoctoral Fellow Positions – Vascular Biology (University of Illinois)

Postdoctoral Position – Modeling and Analysis of Receptor Interactions (UT Southwestern Medical Center)

Postdoctoral Fellow – Molecular Mechanisms of Angiogenesis and Atherosclerosis (The University of Tennessee Health Science Center)

Postdoctoral Scientist – Isoprenoid Metabolism in Angiogenesis and Cancer (VIB)

PhD Positions – Metabolism and Cancer (VIB)

Postdoctoral Fellow/Research Associate – Translational Genomics and Cancer Immunobiology & Immunotherapy (Children’s Hospital of Philadelphia)

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