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Endothelial Cell News
Endothelial Cell News is an online resource dedicated to the latest research studying the endothelium, blood vessels, and angiogenesis.
Glutamatergic Neuronal Activity Regulates Angiogenesis and Blood-Retinal Barrier Maturation via Norrin/β-Catenin Signaling
[Neuron] Using in vivo genetic studies in mice, scRNA-seq, and functional validation, researchers showed that deep plexus angiogenesis and paracellular blood-retinal barrier maturation were delayed in Vglut1−/− retinas where neurons failed to release glutamate.
Endomucin Selectively Regulates Vascular Endothelial Growth Factor Receptor-2 Endocytosis through Its Interaction with AP2
[Cell Communication and Signaling] The authors investigated the molecular mechanism underlying endomucin’s involvement in the regulation of vascular endothelial growth factor-induced endocytosis.
Anti-Lymphangiogenesis for Boosting Drug Accumulation in Tumors
[Signal Transduction and Targeted Therapy] Investigators verified that anlotinib, a tyrosine kinase inhibitor with anti-lymphangiogenesis activity, and SAR131675, a selective VEGFR-3 inhibitor, effectively decreased the density of tumor lymphatic vessels in mouse cancer models.
Canonical and Non-Canonical Roles of Complement in Atherosclerosis
[Nature Reviews Cardiology] Scientists summarize the classical and the emerging non-classical roles of the complement system in the pathogenesis of atherosclerosis.
NYU Langone Health’s New Optimal Aging Institute to Further Explore the Link Between Vascular Health & Aging
[NYU Langone Health] Researchers at the newly formed Optimal Aging Institute at NYU Langone Health have been awarded $31 million by the National Institutes of Health to study how vascular risk factors contribute to dementia and other age-related disorders in those over the age of 85, building upon existing research.
Endothelial DR6 in Blood-Brain Barrier Malfunction in Alzheimer’s Disease
[Cell Death & Disease] Investigators found that brain endothelial death receptor 6 (DR6) levels were significantly reduced in a murine model of Alzheimer's disease at the onset of amyloid-β accumulation.
The Requirement of the Mitochondrial Protein NDUFS8 for Angiogenesis
[Cell Death & Disease] The authors investigated the potential involvement of NADH:ubiquinone oxidoreductase core subunit S8 (NDUFS8) in angiogenesis. In HUVECs and other endothelial cell types, they employed viral shRNA to silence NDUFS8 or employed the CRISPR/Cas9 method to knock it out.
CD32 Captures Committed Haemogenic Endothelial Cells during Human Embryonic Development
[Nature Cell Biology] Researchers performed transcriptomic analysis of 28- to 32-day human embryos and observed that the expression of Fc receptor CD32 was highly enriched in the endothelial cell population that contained hemogenic endothelial cells.
A Brain-Specific Angiogenic Mechanism Enabled by Tip Cell Specialization
[Nature] Investigators revealed a molecular mechanism for brain-specific angiogenesis that operated under the control of Wnt7a/b ligands—well-known blood–brain barrier maturation signals.
Eph-Ephrin Signaling Couples Endothelial Cell Sorting and Arterial Specification
[Nature Communications] Researchers combined cell type-specific and inducible mouse genetics, flow experiments in vitro, single-cell RNA sequencing and biochemistry to show that the balance between ephrin-B2 and its receptor EphB4 was critical for arterial specification, cell sorting, and arteriovenous patterning.
Tobacco Smoke Condensate-Induced Senescence in Endothelial Cells Was Ameliorated by Colchicine Treatment via Suppression of NF-κB and MAPKs P38 and ERK Pathways Activation
[Cell Communication and Signaling] The authors investigated the smoking induced cellular senescence and employed colchicine that blocked senescence in endothelial cells exposed to tobacco smoke condensate.
The Role of Vasculature and Angiogenesis in Respiratory Diseases
[Angiogenesis] The authors outline the importance of vascular remodeling and angiogenesis in a variety of non-neoplastic and neoplastic acute and chronic respiratory diseases such as lung infection, chronic obstructive pulmonary disease, lung fibrosis, pulmonary hypertension, and lung cancer.
Specific research topics covered in Endothelial Cell News include the roles of endothelial cells in the regulation of physiological processes, as well as their implications in tumor progression, cardiovascular disease, endometriosis, wound healing, tissue regeneration and other diseases and disorders. We also provide updates on the latest job postings and upcoming events, helping connect everyone within the endothelial cell research field.
