Endothelial Cell News

Endothelial Cell News is an online resource dedicated to the latest research studying the endothelium, blood vessels, and angiogenesis.

The BulkECexplorer Compiles Endothelial Bulk Transcriptomes to Predict Functional versus Leaky Transcription

[Nature Cardiovascular Research] Researchers presented the BulkECexplorer compendium of 240 bulk RNA-seq datasets from five vascular endothelial cell subtypes. This resource reported transcript counts for genes of interest and predicts whether detected transcripts were likely the products of active or leaky gene expression.

Myricetin Oligomer Triggers Multi-Receptor Mediated Penetration and Autophagic Restoration of Blood-Brain Barrier for Ischemic Stroke Treatment

[ACS Nano] Post ischemic stroke, hypoxia/hypoglycemia provoked the up-regulation of transmembrane glucose transporters and iron transporters due to multiple metabolic disorders, especially in brain endothelial cells. Scientists developed a myricetin oligomer-derived nanostructure doped with Ce to bypass the blood-brain barrier which was cointermediated by glucose transporters and iron transporters such as glucose transporters 1, sodium/glucose cotransporters 1, and transferrin reporter.

Direct Programming of Human Pluripotent Stem Cells into Endothelial Progenitors with SOX17 and FGF2

[Stem Cell Reports] Using single-cell RNA sequencing, researchers investigated transcription factors expressed in endothelial progenitors (EPs) derived from human pluripotent stem cells and identified upregulated expression of SOXF factors SOX7, SOX17, and SOX18 in the EP population.

RIPK1 Inhibitor Ameliorates Pulmonary Injury by Modulating the Function of Neutrophils and Vascular Endothelial Cells

[Cell Death Discovery] Investigators explored the pathological role of RIPK1 in acute lung injury, especially in the pulmonary immune microenvironment involving neutrophils and endothelial cells. In vivo experiments showed that RIPK1 inhibitor protected against lipopolysaccharide-induced lung injury in mouse models, with reduced neutrophils and monocytes infiltration in the lungs.

Homocysteine Metabolites Inhibit Autophagy by Upregulating miR-21-5p, miR-155-5p, miR-216-5p, and miR-320c-3p in Human Vascular Endothelial Cells

[Scientific Reports] Scientists examined the influence of Hcy-thiolactone, N-Hcy-protein, and Hcy on autophagy human umbilical vein endothelial cells. THey found that treatments with Hcy-thiolactone, N-Hcy-protein, or Hcy significantly downregulated beclin 1 (BECN1), autophagy-related 5 (ATG5), autophagy-related 7 (ATG7), and microtubule-associated protein 1 light chain 3 (LC3) mRNA and protein levels.

Engineering Pre-Vascularized 3D Tissue and Rapid Vascular Integration with Host Blood Vessels via Co-Cultured Spheroids-Laden Hydrogel

[Biofabrication] Human adipose-derived stem cells and human umbilical vein cells were prepared as spheroids, which were encapsulated in gelatin methacryloyl hydrogels to fabricate a 3D pre-vascularized tissue.

Mimicking Angiogenic Microenvironment of Alveolar Soft-Part Sarcoma in a Microfluidic Coculture Vasculature Chip

[Proceedings Of The National Academy Of Sciences Of The United States Of America] To mimic alveolar soft-part sarcoma angiogenic microenvironment, a microfluidic coculture vasculature chip has been developed as a 3D spheroid composed of mouse alveolar soft-part sarcoma, a layer of pericytes, and endothelial cells.

SOX17/ETV2 Improves the Direct Reprogramming of Adult Fibroblasts to Endothelial Cells

[Cell Reports Methods] Investigators directly reprogrammed adult human dermal fibroblasts into reprogrammed endothelial cells (ECs) by overexpressing SOX17 in conjunction with ETS variant 2 (ETV2).

Dapagliflozin Promotes White Adipose Tissue Browning through Regulating Angiogenesis in High Fat Induced Obese Mice

[BMC Pharmacology & Toxicology] Scientists explored the role of dapagliflozin on WAT browning in high-fat diet (HFD)-induced obese mice. Male C57BL/6J mice were used to establish an obesity model by following feeding with HFD for 6 weeks.

Autophagy Induced by Low Shear Stress Leads to Endothelial Glycocalyx Disruption

[Journal Of Vascular Research] Human umbilical vein endothelial cells were subjected to physiological shear stress and low shear stress treatments, followed by the application of autophagy inducers and inhibitors. Additionally, cells were treated with specific matrix metalloproteinase-2 and matrix metalloproteinase-9 inhibitor.

Pulmonary Vascular Dysfunctions in Cystic Fibrosis

[Physiology] More recent research has been dedicated to elucidating the role of cystic fibrosis transmembrane conductance regulator in the endothelium. The authors summarize the current knowledge on pulmonary vascular dysfunctions in cystic fibrosis and discuss applicable therapies.

Kdm6a-CNN1 Axis Orchestrates Epigenetic Control of Trauma-Induced Spinal Cord Microvascular Endothelial Cell Senescence to Balance Neuroinflammation for Improved Neurological Repair

[Bone Research] Researchers presented a comprehensive demonstration and characterization of microvascular endothelial cell senescence induced by spinal cord injury. Lysine demethylase 6A, commonly known as UTX, emerged as a crucial regulator of cell senescence in injured spinal cord microvascular endothelial cells.

Specific research topics covered in Endothelial Cell News include the roles of endothelial cells in the regulation of physiological processes, as well as their implications in tumor progression, cardiovascular disease, endometriosis, wound healing, tissue regeneration and other diseases and disorders. We also provide updates on the latest job postings and upcoming events, helping connect everyone within the endothelial cell research field.

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