| Endothelial Cell News 3.06 February 26, 2018 | |
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TOP STORYEndothelial TFEB Positively Regulates Post-Ischemic Angiogenesis Researchers determined the role of endothelial transcription factor-EB (TFEB) in post-ischemic angiogenesis and its underlying molecular mechanism. [Circ Res] Abstract |
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PUBLICATIONS(Ranked by impact factor of the journal)A Human Endothelial Cell-Based Recycling Assay for Screening of FcRn Targeted Molecules Albumin and IgG have remarkably long serum half-lives due to pH-dependent FcRn-mediated cellular recycling that rescues both ligands from intracellular degradation. Increase in half-lives of IgG and albumin-based therapeutics has the potential to improve their efficacies, but there is a great need for robust methods for screening of relative FcRn-dependent recycling ability. Researchers report on a novel human endothelial cell-based recycling assay that can be used for such pre-clinical screening. [Nat Commun] Full Article Angiogenic Patterning by STEEL, an Endothelial-Enriched Long Noncoding RNA Scientists identified lncRNAs that are enriched in endothelial cells (ECs) and further characterized the lncRNA, spliced-transcript endothelial-enriched lncRNA (STEEL). STEEL promoted the formation of intact blood vessels by ECs in vivo. [Proc Natl Acad Sci USA] Abstract | Press Release In vivo studies with stably transfected A431 squamous cell carcinoma cells revealed that full-length thrombospondin-2 (TSP2), but not shorter transcript of TSP2, inhibited tumor growth and angiogenesis. [Oncogene] Full Article From a heterogeneous placental single-cell suspension, a directly flow-sorted CD45−CD34+CD144+CD31Lo population uniquely differentiated into both endothelial and mesenchymal colonies in limiting dilution culture assays. RNA sequencing and functional analysis demonstrated that Notch signaling was a key driver for endothelial and bipotential progenitor function. [Stem Cell Reports] Full Article | Graphical Abstract Investigators found that growth differentiation factor 11 was significantly upregulated and activated in two experimental pulmonary arterial hypertension models and cultured pulmonary artery endothelial cells. [Hypertension] Abstract Ginsenoside Rh2 Inhibits Vascular Endothelial Growth Factor-Induced Corneal Neovascularization Scientists investigated the potential effect of ginsenoside Rh2 (GRh2) on neovascularization. In HUVECs, pretreatment with GRh2 largely attenuated VEGF-induced cell proliferation, migration, and vessel-like tube formation in vitro. [FASEB J] Abstract Investigators demonstrated that in HUVECs, cinnamaldehyde (CA) stimulated proliferation, migration, and tube formation. The secretion of VEGF from HUVECs was increased by CA. [Lab Invest] Abstract The authors report an activation mechanism of a calcium-permeable canonical transient receptor potential 4 (TRPC4) channel by polycystin-1 (PC1) and its endothelial function. They found that the inhibitory Gαi3 protein selectively bound to the G-protein-binding domain on the C-terminus of PC1. [Sci Rep] Full Article Hypoxia-Induced Long Non-Coding RNA Malat1 Is Dispensable for Renal Ischemia/Reperfusion-Injury In vitro, Malat1 inhibition reduced proliferation and the number of endothelial cells in the S-phase of the cell cycle. In vivo, Malat1 knockout and wildtype mice showed similar degrees of outer medullary tubular epithelial injury, proliferation, capillary rarefaction, inflammation and fibrosis, survival and kidney function. [Sci Rep] Full Article SRPKIN-1 was more potent in converting the pro-angiogenic VEGF-A165a to the anti-angiogenic VEGF-A165b isoform and in blocking laser-induced neovascularization in a murine retinal model. [Cell Chem Biol] Abstract | Graphical Abstract Having identified matrix compositions that promote monolayer formation and barrier function, the authors successfully fabricated human brain microvascular endothelial cell microvessels in cross-linked collagen I gels coated with fibronectin and collagen IV, and treated with ROCK inhibitor and cAMP. [Fluids Barriers CNS] Full Article |
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REVIEWSEndothelial Cell Protein C Receptor-Dependent Signaling Endothelial cell protein C receptor (EPCR), a transmembrane glycoprotein present on the surface of endothelial cells and other cell types, is an essential component of the protein C anticoagulant system. EPCR is also shown to play a critical role in mediating activated protein C-induced cytoprotective signaling. Scientists outline the mechanisms of EPCR-dependent cell signaling and discuss recent findings made in this area. [Curr Opin Hematol] Abstract Visit our reviews page to see a complete list of reviews in the endothelial cell research field. |
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INDUSTRY NEWSPfizer Inc. announced that the Committee for Medicinal Products for Human Use of the European Medicines Agency has recommended against expanding use of SUTENT® to include the adjuvant treatment of adult patients at a high risk of recurrent renal cell carcinoma following nephrectomy. [Pfizer Inc.] Press Release ELSALYS BIOTECH has signed a license option agreement with THEA for the development of its ELB011 program in ophthalmology. ELB011, a first-in-class antibody program, demonstrates an anti-angiogenic effect on the formation of new blood vessels which cause certain retinal diseases including age-related macular degeneration. [ELSALYS BIOTECH] Press Release Pitt, UPMC Announce $200 Million Immunotherapy Investment, Creation of Innovation Facility The University of Pittsburgh (Pitt) and University of Pittsburgh Medical Center (UPMC) announced plans to establish the new UPMC Immune Transplant and Therapy Center, with much of its activity planned within an eight-story innovation hub—all part of a concerted effort to harness the power of the human immune system to treat and cure a wide range of diseases. [The University of Pittsburgh Medical Center] Press Release | |
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POLICY NEWSFlorida Residents Could Soon Get the Power to Alter Science Classes Policymakers in the United States are pushing to give the public more power to influence what educators teach students. Florida’s legislature started considering two related bills that, if enacted, would let residents recommend which instructional materials teachers in their school district use in their classrooms. [Nature News] Editorial One of the Most Powerful Science Policy Jobs in Brussels Changes Hands It’s the end of an era at the European Commission’s research department: The most powerful civil servant in Brussels’s science policy circles, Director-General for Research and Innovation Robert-Jan Smits, is leaving his post. [ScienceInsider] Editorial U.K. Scientists Increasingly Anxious about Brexit Confusion With the second phase of Brexit negotiations approaching, scientists in the United Kingdom are urging their government to clarify its position on funding agreements and migration of research talent after the country separates from the European Union in March 2019. [ScienceInsider] Editorial
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EVENTSNEW International Society for Stem Cell Research (ISSCR) 2018 Annual Meeting Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Research Associate – Vascular Biology (Case Western Reserve University) Research Fellow – Endothelial Cell Programming (Birmingham University) Postdoctoral Associate – Bioengineering (University of Pittsburgh) Postdoctoral Research Associate – Vascular Inflammation (University of Illinois) PhD Studentship – Tumor Biology (University College London) Postdoctoral Fellow – Vascular Biology (Weill Cornell Medicine) Postdoctoral Research Fellow – Therapeutic Angiogenesis (University of Michigan) Postdoctoral Fellow – Vascular Biology (City of Hope) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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